Inter holds a heavy historical advantage in this matchup, claiming seven wins from their last ten meetings with Lazio. That mental edge carries weight when traveling to the capital for a high-stakes cup tie.

The home side faces a major defensive crisis ahead of this clash. Starting goalkeeper Ivan Provedel and key center-back Mario Gila are both ruled out through injury, forcing unwanted rotation at the back.

Inter have been ruthless in the final third during this Coppa Italia run. They have netted 10 goals in just four tournament matches, consistently turning high possession into clear scoring chances.

Lazio are not lacking their own punch despite the defensive issues. They have consistently found the net in recent weeks, including impressive multi-goal performances against Atalanta and Napoli.

Cup ties at this stage often force urgency from the opening whistle. With both teams involved in wild, high-scoring domestic fixtures recently, a conservative approach feels highly unlikely.